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Clinical Trials: A Methodologic Perspective
 
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Clinical Trials: A Methodologic Perspective [Format Kindle]

Steven Piantadosi

Prix conseillé : EUR 148,32 De quoi s'agit-il ?
Prix éditeur - format imprimé : EUR 159,57
Prix Kindle : EUR 84,78 TTC & envoi gratuit via réseau sans fil par Amazon Whispernet
Économisez : EUR 74,79 (47%)

  • Longueur : 720 pages
  • Langue : Anglais
  • En raison de la taille importante du fichier, ce livre peut prendre plus de temps à télécharger
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Descriptions du produit

Revue de presse

"…clearly written, practical presentations of the standard topics, and also fascinating discussion you won′t find elsewhere…" ( Journal of Clinical Research Best Practices , August 2007) "…a very good addition to the clinical trials area." ( Statistical Methods in Medical Research , October 2006) "…an excellent reference for both clinicians and statisticians." ( Journal of Biopharmaceutical Statistics , May/June 2006)

"…a very good addition to the clinical trials area." ( Statistical Methods in Medical Research , October 2006) "…an excellent reference for both clinicians and statisticians." ( Journal of Biopharmaceutical Statistics , May/June 2006)

Présentation de l'éditeur

Learn rigorous statistical methods to ensure valid clinical trials

This Second Edition of the critically hailed Clinical Trials builds on the text's reputation as a straightforward and authoritative presentation of statistical methods for clinical trials. Readers are introduced to the fundamentals of design for various types of clinical trials and then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides commonsense solutions.

The author bases the revisions and updates on his own classroom experience, as well as feedback from students, instructors, and medical and statistical professionals involved in clinical trials. The Second Edition greatly expands its coverage, ranging from statistical principles to controversial topics, including alternative medicine and ethics. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First Edition will discover completely new chapters, including:
* Contexts for clinical trials
* Statistical perspectives
* Translational clinical trials
* Dose-finding and dose-ranging designs


Each chapter is accompanied by a summary to reinforce the key points. Revised discussion questions stimulate critical thinking and help readers understand how they can apply their newfound knowledge, and updated references are provided to direct readers to the most recent literature.

This text distinguishes itself with its accessible and broad coverage of statistical design methods--the crucial building blocks of clinical trials and medical research. Readers learn to conduct clinical trials that produce valid qualitative results backed by rigorous statistical methods.

Détails sur le produit

  • Format : Format Kindle
  • Taille du fichier : 11767 KB
  • Nombre de pages de l'édition imprimée : 720 pages
  • Editeur : Wiley-Interscience; Édition : 2 (29 mai 2013)
  • Vendu par : Amazon Media EU S.à r.l.
  • Langue : Anglais
  • ASIN: B00HLGJHEG
  • Synthèse vocale : Activée
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  • Word Wise: Non activé
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Commentaires en ligne

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Commentaires client les plus utiles sur Amazon.com (beta)
Amazon.com: 4.8 étoiles sur 5  6 commentaires
34 internautes sur 35 ont trouvé ce commentaire utile 
5.0 étoiles sur 5 unusually well-written text on the statistical aspects 22 janvier 2008
Par Michael R. Chernick - Publié sur Amazon.com
Format:Relié
This book is very unique. Basic statistical concepts are clearly presented but only those concepts that are important in clinical trials. The author presents all the issues with clinical trials including ethical issues with some historical perspective. Principles of randomization and statistical design are clearly presented. It offers discussion of Bayesian techniques and meta-analyses, cross-over designs and group sequential methods (interim analyses). For statisticians doing clinical research like myself, this is a valuable reference source.
23 internautes sur 23 ont trouvé ce commentaire utile 
5.0 étoiles sur 5 The best start in clinical trial 22 mai 2000
Par Alexandre Santos Aguiar - Publié sur Amazon.com
Format:Relié
The amount of knowledge and the scope of this book are the exact need for the first contact with clinical trials. Yet, it is not a simple or superficial text. Instead, it not only will guide the reader through the basics of trials (and there is so much that is not basic in it) but the author points the reader to hundreds of papers and books that are landmarks. I regard this book itself as one of these landmarks!
18 internautes sur 18 ont trouvé ce commentaire utile 
5.0 étoiles sur 5 Most up-to-date and thorough cover of Clinical Trials 14 janvier 1999
Par Un client - Publié sur Amazon.com
Format:Relié
Covers many aspects of trials (particularly facets of design and analysis)not yet covered by other books, eg randomisation with minimisation, and meta-analysis of trial results. Readable, applicable, practical, good references, well structured.
3 internautes sur 3 ont trouvé ce commentaire utile 
4.0 étoiles sur 5 Excellent book with some challenges 15 juillet 2011
Par Simon Yan - Publié sur Amazon.com
Format:Relié|Achat vérifié
It is a very good course book for graduates in clinical trial design and practice. It is also a great reference for biostatisticians and clinical investigators who have solid knowledge background in biostatistics and mathematics. However, it may be a challenge to understand the detailed statistic and math equations and theories by those clinical scientists in pharmacology, toxicology, PKDM, and even clinical data programmers and project managers in pharmaceutical industry. Since clinical trials in pharmaceutical industry are carried out following FDA and ICH guidelines, those clinical scientists and project managers may expect more practical procedures in clinical trial design and examples of data analyses and statistical decisions for new drugs or decease treatments, which demonstrate how to design and judge clinical trials under FDA and ICH guidelines.
2 internautes sur 2 ont trouvé ce commentaire utile 
5.0 étoiles sur 5 Clinical Trials: A Methodologic Perspective Second Edition 29 mai 2007
Par Edward A. Smith - Publié sur Amazon.com
Format:Relié|Achat vérifié
This is an excellent book. It outlines the important issues of clinical trials well. It is understandable and thorough. A must for anyone who is interested in actually doing trials. Not a good book for a brief, superficial overview.
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