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Immortal Life of Henrietta Lacks [Version intégrale] [Anglais] [Broché]

Rebecca Skloot
4.8 étoiles sur 5  Voir tous les commentaires (9 commentaires client)
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Description de l'ouvrage

7 janvier 2011
#1 NEW YORK TIMES BESTSELLER

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor black tobacco farmer whose cells—taken without her knowledge in 1951—became one of the most important tools in medicine, vital for developing the polio vaccine, cloning, gene mapping, and more. Henrietta's cells have been bought and sold by the billions, yet she remains virtually unknown, and her family can't afford health insurance. This phenomenal New York Times bestseller tells a riveting story of the collision between ethics, race, and medicine; of scientific discovery and faith healing; and of a daughter consumed with questions about the mother she never knew.
--Ce texte fait référence à l'édition Broché .

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Descriptions du produit

Extrait

PROLOGUE
The Woman in the Photograph

There’s a photo on my wall of a woman I’ve never met, its left corner torn and patched together with tape. She looks straight into the camera and smiles, hands on hips, dress suit neatly pressed, lips painted deep red. It’s the late 1940s and she hasn’t yet reached the age of thirty. Her light brown skin is smooth, her eyes still young and playful, oblivious to the tumor growing inside her—a tumor that would leave her five children motherless and change the future of medicine. Beneath the photo, a caption says her name is “Henrietta Lacks, Helen Lane or Helen Larson.”
           
No one knows who took that picture, but it’s appeared hundreds of times in magazines and science textbooks, on blogs and laboratory walls. She’s usually identified as Helen Lane, but often she has no name at all. She’s simply called HeLa, the code name given to the world’s first immortal human cells—her cells, cut from her cervix just months before she died.
           
Her real name is Henrietta Lacks.

I’ve spent years staring at that photo, wondering what kind of life she led, what happened to her children, and what she’d think about cells from her cervix living on forever—bought, sold, packaged, and shipped by the trillions to laboratories around the world. I’ve tried to imagine how she’d feel knowing that her cells went up in the first space missions to see what would happen to human cells in zero gravity, or that they helped with some of the most important advances in medicine: the polio vaccine, chemotherapy, cloning, gene mapping, in vitro fertilization. I’m pretty sure that she—like most of us—would be shocked to hear that there are trillions more of her cells growing in laboratories now than there ever were in her body.
            
There’s no way of knowing exactly how many of Henrietta’s cells are alive today. One scientist estimates that if you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—an inconceivable number, given that an individual cell weighs almost nothing. Another scientist calculated that if you could lay all HeLa cells ever grown end-to-end, they’d wrap around the Earth at least three times, spanning more than 350 million feet. In her prime, Henrietta herself stood only a bit over five feet tall.
          
I first learned about HeLa cells and the woman behind them in 1988, thirty-seven years after her death, when I was sixteen and sitting in a community college biology class. My instructor, Donald Defler, a gnomish balding man, paced at the front of the lecture hall and flipped on an overhead projector. He pointed to two diagrams that appeared on the wall behind him. They were schematics of the cell reproduction cycle, but to me they just looked like a neon-colored mess of arrows, squares, and circles with words I didn’t understand, like “MPF Triggering a Chain Reaction of Protein Activations.”
            
I was a kid who’d failed freshman year at the regular public high school because she never showed up. I’d transferred to an alternative school that offered dream studies instead of biology, so I was taking Defler’s class for high-school credit, which meant that I was sitting in a college lecture hall at sixteen with words like mitosis and kinase inhibitors flying around. I was completely lost.
           
“Do we have to memorize everything on those diagrams?” one student yelled.
           
Yes, Defler said, we had to memorize the diagrams, and yes, they’d be on the test, but that didn’t matter right then. What he wanted us to understand was that cells are amazing things: There are about one hundred trillion of them in our bodies, each so small that several thousand could fit on the period at the end of this sentence. They make up all our tissues—muscle, bone, blood—which in turn make up our organs.
           
Under the microscope, a cell looks a lot like a fried egg: It has a white (the cytoplasm) that’s full of water and proteins to keep it fed, and a yolk (the nucleus) that holds all the genetic information that makes you you. The cytoplasm buzzes like a New York City street. It’s crammed full of molecules and vessels endlessly shuttling enzymes and sugars from one part of the cell to another, pumping water, nutrients, and oxygen in and out of the cell. All the while, little cytoplasmic factories work 24/7, cranking out sugars, fats, proteins, and energy to keep the whole thing running and feed the nucleus. The nucleus is the brains of the operation; inside every nucleus within each cell in your body, there’s an identical copy of your entire genome. That genome tells cells when to grow and divide and makes sure they do their jobs, whether that’s controlling your heartbeat or helping your brain understand the words on this page.
            
Defler paced the front of the classroom telling us how mitosis—the process of cell division—makes it possible for embryos to grow into babies, and for our bodies to create new cells for healing wounds or replenishing blood we’ve lost. It was beautiful, he said, like a perfectly choreographed dance.
           
All it takes is one small mistake anywhere in the division process for cells to start growing out of control, he told us. Just one enzyme misfiring, just one wrong protein activation, and you could have cancer. Mitosis goes haywire, which is how it spreads.
           
“We learned that by studying cancer cells in culture,” Defler said. He grinned and spun to face the board, where he wrote two words in enormous print: HENRIETTA LACKS.
          
Henrietta died in 1951 from a vicious case of cervical cancer, he told us. But before she died, a surgeon took samples of her tumor and put them in a petri dish. Scientists had been trying to keep human cells alive in culture for decades, but they all eventually died. Henrietta’s were different: they reproduced an entire generation every twenty-four hours, and they never stopped. They became the first immortal human cells ever grown in a laboratory.
            
“Henrietta’s cells have now been living outside her body far longer than they ever lived inside it,” Defler said. If we went to almost any cell culture lab in the world and opened its freezers, he told us, we’d probably find millions—if not billions—of Henrietta’s cells in small vials on ice.
            
Her cells were part of research into the genes that cause cancer and those that suppress it; they helped develop drugs for treating herpes, leukemia, influenza, hemophilia, and Parkinson’s disease; and they’ve been used to study lactose digestion, sexually transmitted diseases, appendicitis, human longevity, mosquito mating, and the negative cellular effects of working in sewers. Their chromosomes and proteins have been studied with such detail and precision that scientists know their every quirk. Like guinea pigs and mice, Henrietta’s cells have become the standard laboratory workhorse.
            
“HeLa cells were one of the most important things that happened to medicine in the last hundred years,” Defler said.
            
Then, matter-of-factly, almost as an afterthought, he said, “She was a black woman.” He erased her name in one fast swipe and blew the chalk from his hands. Class was over.
           
As the other students filed out of the room, I sat thinking, That’s it? That’s all we get? There has to be more to the story.
           
I followed Defler to his office.
            
“Where was she from?” I asked. “Did she know how important her cells were? Did she have any children?”
            
“I wish I could tell you,” he said, “but no one knows anything about her.”
           
After class, I ran home and threw myself onto my bed with my biology textbook. I looked up “cell culture” in the index, and there she was, a small parenthetical:
In culture, cancer cells can go on dividing indefinitely, if they have a continual supply of nutrients, and thus are said to be “immortal.” A striking example is a cell line that has been reproducing in culture since 1951. (Cells of this line are called HeLa cells because their original source was a tumor removed from a woman named Henrietta Lacks.)

That was it. I looked up HeLa in my parents’ encyclopedia, then my dictionary: No Henrietta.
           
As I graduated... --Ce texte fait référence à l'édition Broché .

Revue de presse

#1 NEW YORK TIMES BESTSELLER
Entertainment Weekly #1 Nonfiction Book of the Year
New Yorker Reviewers’ Favorite
American Library Association Notable Book
People Top Ten Book of the Year
Washington Post Book World Top Ten Book of the Year
Salon.com Best Book of the Year
USA Today Ten Books We Loved Reading
O, The Oprah Magazine Top Ten Book of the Year
National Public Radio Best of the Bestsellers
Boston Globe Best Nonfiction Book of the Year  
Financial Times Nonfiction Favorite
Los Angeles Times Critics’ Pick
Bloomberg Top Nonfiction
New York magazine Top Ten Book of the Year
Slate.com Favorite Book of the Year
TheRoot.com Top Ten Book of the Year
Discover magazine 2010 Must-Read
Publishers Weekly Best Book of the Year
Library Journal Top Ten Book of the Year
Kirkus Reviews Best Nonfiction Book of the Year
U.S. News & World Report Top Debate-Worthy Book
Booklist Top of the List—Best Nonfiction Book
New York Times/Science Bestseller list 

“I could not put the book down . . . The story of modern medicine and bioethics—and, indeed, race relations—is refracted beautifully, and movingly.”
Entertainment Weekly

“Science writing is often just about ‘the facts.’ Skloot’s book, her first, is far deeper, braver, and more wonderful.” —New York Times Book Review

The Immortal Life of Henrietta Lacks is a triumph of science writing...one of the best nonfiction books I have ever read.” —Wired.com

A deftly crafted investigation of a social wrong committed by the medical establishment, as well as the scientific and medical miracles to which it led.”
—Washington Post

Riveting...a tour-de-force debut.” —Chicago Sun-Times

“A real-life detective story, The Immortal Life of Henrietta Lacks probes deeply into racial and ethical issues in medicine . . . The emotional impact of Skloot’s tale is intensified by its skillfully orchestrated counterpoint between two worlds.”
Nature

“A jaw-dropping true story . . . raises urgent questions about race and research for ‘progress’ . . . an inspiring tale for all ages.” Essence

“This extraordinary account shows us that miracle workers, believers, and con artists populate hospitals as well as churches, and that even a science writer may find herself playing a central role in someone else’s mythology.” The New Yorker
  
“Has the epic scope of Greek drama, and a corresponding inability to be easily
explained away.” SF Weekly
 
“One of the great medical biographies of our time.” The Financial Times
  
“Like any good scientific research, this beautifully crafted and painstakingly researched book raises nearly as many questions as it answers . . . In a time when it’s fashionable to demonize scientists, Skloot generously does not pin any sins to the lapels of the researchers. She just lets them be human . . . [and] challenges much of what we believe of ethics, tissue ownership, and humanity.” Science
  
“Indelible . . . The Immortal Life of Henrietta Lacks is a heroic work of cultural and medical journalism.” —Laura Miller, Salon.com
  
“No dead woman has done more for the living . . . a fascinating, harrowing, necessary book.” —Hilary Mantel, The Guardian (U.K.)
 
The Immortal Life of Henrietta Lacks does more than one book ought to be able to do.” Dallas Morning News

“Above all it is a human story of redemption for a family, torn by loss, and for a writer with a vision that would not let go.” Boston Globe

 “This remarkable story of how the cervical cells of the late Henrietta Lacks, a poor black woman, enabled subsequent discoveries from the polio vaccine to in vitro fertilization is extraordinary in itself; the added portrayal of Lacks's full life makes the story come alive with her humanity and the palpable relationship between race, science, and exploitation." —Paula J. Giddings, author of Ida, A Sword Among Lions; Elizabeth A. Woodson 1922 Professor, Afro-American Studies, Smith College
  
“Skloot’s engaging, suspenseful book is an incredibly welcome addition for non-science wonks.” Newsweek

“Extraordinary . . . If science has exploited Henrietta Lacks [Skloot] is determined not to. This biography ensures that she will never again be reduced to cells in a petri dish: she will always be Henrietta as well as HeLa.” The Telegraph (U.K.)
 
“Brings the Lacks family alive . . . gives Henrietta Lacks another kind of immortality—this one through the discipline of good writing.” Baltimore Sun

“A work of both heart and mind, driven by the author’s passion for the story, which is as endlessly renewable as HeLa cells.” Los Angeles Times
 
“In this gripping, vibrant book, Rebecca Skloot looks beyond the scientific marvels to explore the ethical issues behind a discovery that may have saved your life.”
Mother Jones
 
“More than ten years in the making, it feels like the book Ms. Skloot was born to write . . . Skloot, a young science journalist and an indefatigable researcher, writes about Henrietta Lacks and her impact on modern medicine from almost every conceivable angle and manages to make all of them fascinating . . . a searching moral inquiry into greed and blinkered lives . . . packed with memorable characters.” —Dwight Garner, New York Times, Top Ten Book of 2010
 
“Astonishing . . .No matter how much you may know about basic biology, you will be amazed by this book." The Journal of Clinical Investigation

“Rebecca Skloot did her job, and she did it expertly . . . A riveting narrative that is wholly original.” —THEROOT.COM
 
“Moving . . .” The Economist
 
“Journalist Rebecca Skloot’s history of the miraculous cells reveals deep injustices in U.S. medical research.” TIME
 
The Immortal Life of Henrietta Lacks is a fascinating look at the woman whose cultured cells—the first to grow and survive indefinitely, harvested without compensation or consent—have become essential to modern medicine.” Vogue
 
The Immortal Life of Henrietta Lacks is a remarkable feat of investigative journalism and a moving work of narrative nonfiction that reads with the vividness and urgency of fiction. It also raises sometimes uncomfortable questions with no clear-cut answers about whether people should be remunerated for their physical, genetic contributions to research and about the role of profit in science.”
National Public Radio
 
“An indelible, marvelous story as powerful as those cells.” Philadelphia Inquirer
 
“As much an act of justice as one of journalism.” Seattle Times
 
“A stunning book . . . surely the definitive work on the subject.” The Independent(U.K.)
 
“Graceful . . . I can’t think of a better way to capture the corrosive effects of ethical transgressions in medical research. It’s a heartbreaking story, beautifully rendered.” The Lancet
 
“Read this . . . By letting the Lackses be people, and by putting them in the center of the history, Skloot turns just another tale about the march of progress into a complicated portrait of the interaction between science and human lives. —BOINGBOING.NET
 
“[A] remarkable and moving book . . . a vivid portrait of Lacks that should be as abiding as her cells.” The Times (U.K.)
 
“I can’t imagine a better tale. A detective story that’s at once mythically large and painfully intimate. I highly recommend this book.” —Jad Abumrad, Radiolab
 
“Skloot is a terrific popularizer of medical science, guiding readers through this dense material with a light and entertaining touch.” The Globe and Mail (Canada)
 
“A rare and powerful combination of race, class, gender,medicine, bioethics, and intellectual property; far more rare is the writer that can so clearly fuse those disparate threads into a personal story so rich and compelling.” Seed
 
“Powerful story . . . I feel moved even to say on behalf of the thousands of anonymous black men and women who’ve been experimented on for medical purposes, thank you. Thank you for writing this important book.” —Kali-AhsetAmen, Radio Diaspora
 
“Skloot has written an important work of immersive nonfiction that brings not only the stories of Henrietta Lacks and HeLa once more into line, but also catharsis to a family in sore need of it.” The Times Literary Suppleme... --Ce texte fait référence à l'édition Broché .


Détails sur le produit

  • Broché: 384 pages
  • Editeur : Pan Books; Édition : Unabridged (7 janvier 2011)
  • Langue : Anglais
  • ISBN-10: 0330533444
  • ISBN-13: 978-0330533447
  • Dimensions du produit: 13,2 x 19,7 cm
  • Moyenne des commentaires client : 4.8 étoiles sur 5  Voir tous les commentaires (9 commentaires client)
  • Classement des meilleures ventes d'Amazon: 52.435 en Livres anglais et étrangers (Voir les 100 premiers en Livres anglais et étrangers)
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2 internautes sur 2 ont trouvé ce commentaire utile 
5.0 étoiles sur 5 Excellent 26 juillet 2010
Format:Broché
A wonderful literary discovery. "The Immortal Life..." is a real page-turner.
This is the true story of yet another hero who has remained anonymous for too long. The author did a great job in presenting Henrietta Lacks with humanity. Beautifully written with compassion and honesty and extremely well-documented.
5 stars and more.
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5.0 étoiles sur 5 Brigitta 18 avril 2014
Format:Format Kindle
This bookd reads like a fiction thriller, gives an insight into the American system of health and medical research during the mid-20th century.
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3.0 étoiles sur 5 What a story! 15 janvier 2014
Format:Format Kindle|Achat vérifié
This was a really unbelievable story, that it is hard to believe this really happened. I found the book fascinating and very sad too.
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5.0 étoiles sur 5 The Immortaliser Life of Henrietta Lacks 19 octobre 2013
Format:Format Kindle
As a biologist who has cultured HeLa cells myself, it was fascinating to learn the dramatic human story behind the cells as well as realizing that the laws dealing with informed consent that we take for granted are so recent. This book is a fascinating mixture of science, ethics and amazing family story.
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5.0 étoiles sur 5 The Immortal Life of Henrietta Lacks 1 juin 2013
Format:Format Kindle|Achat vérifié
Written with clear intelligence and beauty, it has the structure of a detective novel (you can't put it down) yet it is a true story that spans decades of medical research for a cure for cancer, and the tragic life of the woman who made this research possible. The finest book I have read in a year.
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