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The Quest for the Cure - The Science and Stories Behind the Next Generation of Medicines [Anglais] [Relié]

Brent Stockwell
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Détails sur le produit

  • Relié: 256 pages
  • Editeur : Columbia University Press; Édition : 1 (17 mai 2011)
  • Langue : Anglais
  • ISBN-10: 0231152124
  • ISBN-13: 978-0231152129
  • Dimensions du produit: 22 x 15 x 2 cm
  • Moyenne des commentaires client : 5.0 étoiles sur 5  Voir tous les commentaires (1 commentaire client)
  • Classement des meilleures ventes d'Amazon: 129.267 en Livres anglais et étrangers (Voir les 100 premiers en Livres anglais et étrangers)
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Commentaires client les plus utiles
5.0 étoiles sur 5 Excellent Quest for the Cure 4 janvier 2013
Format:Relié
Excellent bouquin, avis à tous ceux que le monde du médicament intéresse, une analyse longitudinale historique très claire et enlevée
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Amazon.com: 4.2 étoiles sur 5  13 commentaires
11 internautes sur 12 ont trouvé ce commentaire utile 
4.0 étoiles sur 5 Informative (and dense) account of drug discovery 16 mai 2011
Par Sreeram Ramakrishnan - Publié sur Amazon.com
Format:Relié
Drawing heavily from his research & academic backgrounds, Stockwell provides an informative account on drug discovery challenges and ongoing/potential approaches to address them. For a reader with medical background, this is an excellent read while a general reader will struggle with the details. (3.5*)

(Review adapted from my blog; free advance copy provided by the publisher)

At the very outset, Stockwell provides a succinct explanation of why drug discovery is far more challenging than what one may imagine - by focusing on the actual mechanics of "small drug molecules" and proteins involved in disease progression. (A reader can easily grasp this complexity when Stockwell highlights that only 2% of the proteins are now considered "druggable" and the generally risk-averse scientists typically tend to focus only on this minority due to commercial considerations.) The discussion on how drugs actually work may be of interest to the average reader. He then describes (with various examples) various drug discovery mechanisms and a history of cancer drugs. The role of luck in discoveries, of course, is well known...but through these discussions, one gets to appreciate not only the role of luck but also of perseverance and a systematic approach to design experiments. A subsequent chapter on the author's entrepreneurial experience provides some insights on the potential of studying combinations of approved drugs - but the narration is too focused on the company history, a reader is likely to be distracted.

The second part starts with an introduction to promising emerging techniques of drug discovery including structure-based designs, virtual screening, and fragment-based screening. He discusses the origin and potential of these techniques (sometimes a bit too detailed for an average reader), including aspects related to protein-protein interactions and emergence of personalized medicine. Then, the discussion takes on a far more technical density highlighting protein redactions, tagging and libraries for complex structures, biologics and some suggestions that border mostly on policies than technological issues.

One of the main issues with the book is it is not clear who the intended audience is and what level of details is expected of them. The narration (first-person account) appears to alternate between targeting students/new researchers and experienced peers, with a generous autobiographical component in between. This mosaic of narrative tones is very demanding on the reader and oftentimes tangential to the central themes. An average reader with a cursory knowledge about drug chemistry will likely gain from the first part of the book in understanding the complexities of drug development and also various background (very technical) of some of the classes of drugs and some better known biotech companies. The second part is likely to be beneficial for students of this field or those in the drug development ecosystem.

Perhaps, it is a reflection of the complexity of the topic - despite the best efforts of the author to make it accessible to a wider audience; the book is unlikely to sustain the interest of a reader with a non-medical background. The constant intertwining of autobiographical narration, historical vignettes of key personalities and the scientific research being discussed makes for a very challenging read... but well worth it for someone in this field by providing a realistic assessment of the potential for new drug discoveries. (3.5*)
7 internautes sur 8 ont trouvé ce commentaire utile 
5.0 étoiles sur 5 Great Book of Insights into Drug Development 11 juin 2011
Par Dr. Bojan Tunguz - Publié sur Amazon.com
Format:Relié
Modern medicine has immensely improved and in many cases dramatically changed our lives. Many diseases that have until relatively recently been considered incurable have been tackled and overcome. Mapping of the entire human genome at the beginning of the twenty-first century, as well as many novel techniques for developing and testing of the new drugs, have all contributed to the sense that even greater medical breakthroughs are just around the corner. However, this promise has remained not much more than hype. In fact, truly new medicinal drugs are becoming more and more rare, and the time between their development and when they hit the market is ever increasing.

This book aims to give the reader an idea what are drugs from a molecular point of view, and how they affect our bodies. Drugs are relatively small molecules that bind to specific cell proteins and change their function. Coming up with the right kind of small molecule that would do the job is immensely difficult. There is an innumerable amount of potential drug candidates, and choosing the right ones is as much of an art as it is science. Even so, there is a very real possibility that the vast majority of proteins might be "undruggable," i.e. there are no small molecules that would bind to them. The book explores these possibility in some detail, and it offers possible alternative approaches to drugs that could go around the current impediments.

The book is a great mixture of science, medical technology, and business. It provides invaluable insights into the development of new drugs, and the limitations of the current approaches. It also introduces the reader to the world of medical research startups, and the way that these small companies are redefining the drug discovery business.

There have been quite a few books in recent years about the new advances in biotechnology and genetics, but most of them don't provide much in terms of new insight and truly novel information. This book is one of those rare gems that are simultaneously exceedingly readable, as well as do justice to science. After reading it I know quite a bit more about drugs than I did before.
3 internautes sur 3 ont trouvé ce commentaire utile 
5.0 étoiles sur 5 Great treatment of an interesting topic 31 août 2011
Par Carolyn Hancock - Publié sur Amazon.com
Format:Relié|Achat vérifié
A great book. The author writes accessibly for the lay person and makes his tale interesting. My son is studying chemical engineering and is interested in biomedical topics, so we are enjoying reading about current happenings in the search for cures to difficult diseases. I appreciate the level of detail presented with the care taken to explain things as directly as possible. I have learned a lot. It is instructive and inspiring to learn of the author's early ambitions, lessons learned and his successes.
4 internautes sur 6 ont trouvé ce commentaire utile 
3.0 étoiles sur 5 An engaging book on the future of drug discovery 29 mai 2011
Par BLehner - Publié sur Amazon.com
Format:Relié
Introducing the reader to the fascinating and important topic of the future of drug development, Brent R. Stockwell explores how scientists are trying to find new treatments for seemingly uncurable diseases and the need for innovative new approaches in his book The Quest For The Cure.
With an in depth look at both the medical angle, as well as the crucial role of the pharmaceutical industry, this is, for the most parts, a comprehensibly written book on the matter. Aimed at a general audience the narrative of the book is unfortunately varying strongly between easily to comprehend chapters and chapters in which I admittedly had troubles when it came to understand all the chemical and biological details the author provided. You could say, a little medical background knowledge certainly won't hurt when reading the book.
From the scientific achievements of the twentieth century, to the proteins involved in the search for medicines, straight to new approaches in drug design and promising emerging techniques of drug discovery, Stockwell gives the reader a wide overview on the topic. The author also shares his entrepreneurial experience with insights on the potential of studying combinations of approved drugs, giving the book an autobiographic touch. Personally I would have wished for less scientific details and a closer look at the industry as such. Nonetheless an interesting read in which I learned quite a few new things!
In short: An engaging book on the future of drug discovery!

Disclosure of Material Connection: I received this book free from the publisher through the NetGalley.com book review program. I was not required to write a positive review. The opinions I have expressed are my own. I am disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255 : "Guides Concerning the Use of Endorsements and Testimonials in Advertising."
2 internautes sur 3 ont trouvé ce commentaire utile 
5.0 étoiles sur 5 "The future of medicine is balanced on the fulcrum of the undruggable proteins." 8 octobre 2011
Par ROROTOKO - Publié sur Amazon.com
Format:Relié
This book is on the Rorotoko list. Professor Stockwell's interview on "The Quest for the Cure" ran as the Rorotoko Cover Feature on July 25, 2011 (and can be read in the Rorotoko archive).
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